A Doctor’s Breakdown of GLP-1 Medications: Weight Management, Benefits, and Risks
The webinar, “Is Ozempic the New Gym? The Truth About GLP-1s,” provided an overview of GLP-1s and their role in the current weight-management industry.
What Are GLP-1s?
Dr. Standifer started by explaining what GLP-1 actually is. GLP-1 is a hormone your body already makes. Its job is to slow digestion, help regulate blood sugar, and signal to your brain that you’re full. GLP-1 medications work by mimicking this hormone, which can reduce appetite and help with weight loss over time.
She walked through the different types of GLP-1 medications, including Trulicity, Victoza, Saxenda, Wegovy, Rybelsus, semaglutide, and tirzepatide. One key distinction she highlighted is that tirzepatide acts on two hormone pathways, GLP-1 and GIP, which may make it more effective for some people in terms of fat loss, metabolism, and insulin resistance.
Are GLP-1 Medications “Better” Than Others?
One of the most common questions was whether injectables are better than oral options. According to Dr. Standifer, injectable GLP-1s are generally more effective for weight loss than oral versions. That said, effectiveness always depends on the individual, their medical history, and the consistency with which the medication is used under medical supervision.
She also made it clear that these medications are not appropriate for everyone. Certain conditions, including a history of medullary thyroid cancer, uncontrolled blood sugar, diabetic eye disease, or gallbladder issues, can make GLP-1s unsafe. This is why she stressed repeatedly that anyone considering these medications should work closely with their healthcare provider and not rely on online shortcuts or unregulated versions.
Weight Loss vs. Weight Management
One of the key takeaways from the conversation was that GLP-1s are not quick-fix weight-loss drugs.
Dr. Standifer emphasized that obesity is a chronic medical condition, not a personal failure or a temporary problem. For many people, GLP-1 medications are part of long-term weight management, not something you take for a few months and stop. In fact, stopping these medications often leads to weight regain, which can feel discouraging if expectations weren’t set upfront.
She also explained that rapid weight loss can come with downsides, including muscle loss, hair shedding, fatigue, and nutrient deficiencies. That’s why weight management on GLP-1s should always include adequate protein intake, strength training, and proper nutrition.
Who May Benefit Most?
Dr. Standifer noted that GLP-1 medications can be especially helpful for certain groups, including menopausal women, people with PCOS, breast cancer survivors, and anyone struggling with insulin resistance. These medications can help address the hormonal and metabolic shifts that make weight gain more stubborn during midlife.
That said, side effects are real. Common ones include nausea, constipation, sulfur burps, and temporary hair loss. Many of these can be minimized by eating enough protein, staying hydrated, and adjusting dosage slowly with a provider’s guidance.
Lifestyle Still Matters
Even with medication, Dr. Standifer stressed that diet and movement still matter. GLP-1s are most effective when paired with balanced meals, regular exercise, and realistic expectations. She noted that many women underestimate their protein needs and recommended about 90 grams per day for weight maintenance and muscle support. For those who don’t eat much meat, she mentioned protein shakes as a helpful option.
The discussion also touched on supplements, including vitamin D. Dr. Standifer shared that vitamin D3 is more effective than D2 and recommended taking it year-round, especially for people living in colder climates or spending limited time in the sun.
The Bottom Line
The webinar's key message was simple but important: GLP-1 medications can be powerful tools, but they are not a magic bullet. They work best as part of a thoughtful, long-term approach to health that includes proper nutrition, regular physical activity, and medical guidance.
If you’re curious about GLP-1s, feeling confused by the headlines, or wondering whether they’re right for you, the best next step is a conversation with your healthcare provider. Your body, health history, and goals matter, and weight management should never be one-size-fits-all.
As Dr. Standifer reminded us, sustainable health is about support, not shortcuts!